Advances in the treatment of advanced estrogen receptor positive breast cancer

Luminal estrogen receptor positive HER-2 negative breast cancer is the common type of breast cancer, accounting for 70%  of all breast cancer. Endocrine therapy of estrogen receptor positive HER2 negative advanced breast cancer is very effective, however, many patients will have disease recurrence as a result of endocrine therapy emerging resistance. In this post, I will review our recent understanding of resistance mechanisms how this understanding translating into new therapies.

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